Research
From question to evidence.
01 · In silico
Benchmarking
Does Neoantigen Retriever rank known immunogenic targets above background?
Evidence
- Public and curated datasets
- Comparison with established tools
- Qualitative ranking review
02 · In vitro
Wet-Lab Validation
Do prioritized candidates bind DLA molecules and elicit immune responses?
Evidence
- Binding / stability assays
- ELISpot
- Tumour-recognition experiments
03 · In vivo
Conditional evaluation
If supported, is an investigational vaccine safe and immunologically active?
Evidence
- Authorized clinical protocol
- Safety observations
- Immune monitoring
Participation
Two separate decisions, made at different times.
Sample-study participation
An owner and veterinarian agree to contribute samples and clinical context for research. This does not imply later vaccination.
- 1Clinical suitability review
- 2Informed owner consent
- 3Sample collection & sequencing
Later vaccination eligibility
Assessed only if laboratory evidence supports candidates and an authorized protocol exists.
- 1Evidence review
- 2Clinical re-assessment
- 3Protocol-specific consent
Clinical eligibility criteria will be defined with the veterinary team as the study develops.
The original prototype
Explore the work that started it.
Project Rosie is the earlier hackathon prototype. These resources show its design and execution; experimental and clinical validation are the next development stages.